Skeletal muscle weakness, fatigue and sarcoidosis
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چکیده
منابع مشابه
Skeletal muscle weakness, fatigue and sarcoidosis.
S arcoidosis is a multisystem granulomatous disorder that may involve many organs. Beside organ specific symptoms, non-specific constitutional complaints such as fatigue and general weakness are frequent. The granuloma formation in sarcoidosis is driven by an array of cytokines such as tumour necrosis factor (TNF)-a, interleukin (IL)-6, interferon (INF)-c and others. High circulating levels of ...
متن کاملPhysiological analysis of skeletal muscle weakness and fatigue.
Over a century ago Duchenne summarized his life's work in the third edition of his famous book De L'electrisation Localisee (1872), which laid the foundation of electrophysiology of muscle and clinical myology. Primary muscle diseases are ad mittedly uncommon but, for the sufferers and their families, of grave import since for most no effec tive therapy is as yet available. However, skeletal ...
متن کاملSymptomatic sarcoidosis of skeletal muscle.
Two patients with chronic sarcoid myopathy are described. Both were middle-aged females and both showed the features of pseudohypertrophy. In other aspects they contrasted markedly. In one (A.R.) the sheer volume of granuloma and its effect on muscle fibres was sufficient to explain the muscle weakness and electromyography confirmed a pure myopathy. In the other (J.W.) the muscle granuloma was ...
متن کاملSkeletal muscle fatigue: cellular mechanisms.
Repeated, intense use of muscles leads to a decline in performance known as muscle fatigue. Many muscle properties change during fatigue including the action potential, extracellular and intracellular ions, and many intracellular metabolites. A range of mechanisms have been identified that contribute to the decline of performance. The traditional explanation, accumulation of intracellular lacta...
متن کاملSkeletal muscle weakness in patients with sarcoidosis and its relationship with exercise intolerance and reduced health status.
BACKGROUND Skeletal muscle weakness is assumed to be present in patients with sarcoidosis but has never been reported in a consecutive group of patients. Moreover, its relationship with previously observed exercise intolerance and reduced health status has never been studied in these patients. METHODS Pulmonary function, skeletal and respiratory muscle forces, peak and functional exercise cap...
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ژورنال
عنوان ژورنال: Thorax
سال: 2005
ISSN: 0040-6376
DOI: 10.1136/thx.2004.027342